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Antiviral Etkili Fitoterapötikler: Tıbbi Bitkiler ve Fitokimyasallar

Year 2020, Volume: 1 Issue: 2, 2 - 20, 09.05.2020

Abstract

Viral enfeksiyonlar her yıl milyonlarca kişiyi etkiler ve genel olarak ağır seyreden enfeksiyonlara ve hatta ölümlere sebep olurlar. Yaygın olarak kullanılan antiviral ilaçların genellikle etkinlikleri sınırlıdır ve ciddi yan etkilere sebep olabilirler. Bu nedenle etkili yeni antiviral stratejilere halen çok ihtiyaç duyulmaktadır.
Tıbbi bitkiler eski zamanlardan beri terapötik amaçlar için kullanılmaktadır. Antiviral özellikleri ile doğal bazlı fitoterapi viral hastalıkların tedavisi için uygun bir seçenek olabilir. Genel olarak viral replikasyonun inhibisyonu çoğu zaman doğal ürünlerin antiviral aktivitesi için genel bir mekanizma olarak düşünülse de çalışmalar bazı doğal ürünlerin virülans ile ilişkili anahtar viral proteinlerle etkileşime girebileceğini göstermiştir. Bu anlamda, bazı doğal kaynaklı bileşiklerin kendileri veya bir ana şablon olarak kullanılarak sentezlenen türevleri, daha etkili yeni antiviral ilaç tasarımlarının geliştirilmesine ışık tutabilir. Ayrıca antiviral aktiviteye sahip çok sayıda doğal ürün, bazı epidemilerde genel popülasyonun bağışıklığını arttırmak için kullanılabilecek gıda takviyelerinin de ana bileşenleridir. Antiviral tedavinin zorlukları ve olasılıkları göz önüne alındığında bu çalışma; tıbbi bitkiler ve antiviral aktiviteye sahip olan fitokimyasallar hakkında kanıta dayalı verileri derlemeyi amaçlamaktadır.

Supporting Institution

Bulunmamaktadır.

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Phytotherapeutics with Antiviral Effect: Medicinal Plants and Phytochemicals

Year 2020, Volume: 1 Issue: 2, 2 - 20, 09.05.2020

Abstract

Viral infections affect millions of people each year and generally cause severe infections and even deaths. Commonly used antiviral drugs often have limited efficacy and can cause serious side effects, and therefore effective new antiviral strategies are still needed.
Medicinal plants have been used for therapeutic purposes since ancient times and natural-based phytotherapeutics with their antiviral properties can be an effective option for the treatment of viral diseases. Although inhibition of viral replication is often thought to be a general mechanism for antiviral activity of natural products, studies have shown that some natural products may also interact with virulence-related key viral proteins. In this sense, derivatives of some naturally sourced compounds themselves or synthesized using them as a master template may shed light on developing more effective new antiviral drug designs. In addition, many natural products with antiviral activity are the main components of food supplements that can be used in some epidemics to increase the immunity of the general population. Given the challenges and possibilities of antiviral therapy, this study aims to compile evidence-based data on medicinal plants and related phytochemicals with antiviral activity.

References

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  • Armanini, D., Fiore, C., Mattarello, M.J., Bielenberg, J., & Palermo, M. (2002). History of the Endocrine Effects of Licorice. Experimental and Clinical Endocrinology and Diabetes, 110(6), 257-261. https://doi.org/10.1055/s-2002-34587
  • Bachmetov, L., Gal-Tanamy, M., Shapira, A., Vorobeychik, M., Giterman-Galam, T., Sathiyamoorthy, P., … Zemel, R. (2012). Suppression of Hepatitis C Virus by the Flavonoid Quercetin Is Mediated by Inhibition of NS3 Protease Activity. Journal of Viral Hepatitis, 19(2), e81-88. https://doi.org/10.1111/j.1365-2893.2011.01507.x
  • Ben-Shabat, S., Yarmolinsky, L., Porat, D., & Dahan, A. (2020). Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies. Drug Delivery and Translational Research, 10(2), 354-367. https:// doi: 10.1007/s13346-019-00691-6. Blumenthal M, Goldberg A, Brinckmann J, Foster S. 2000. Herbal Medicine. Expanded Commission E Monographs, American Botanical Council: Austin TX, 233–239.
  • Chang, J.S., Wang, K.C., Yeh, C.F., Shieh, D.E., & Chiang, L.C. (2013). Fresh Ginger (Zingiber Officinale) Has Anti-Viral Activity against Human Respiratory Syncytial Virus in Human Respiratory Tract Cell Lines. Journal of Ethnopharmacology, 145(1), 146-151. https://doi.org/10.1016/j.jep.2012.10.043
  • Chen, C.N., Lin, C.P., Huang, K.K., Chen, W.C., Hsieh, H.P., Liang, P.H., & Hsu, J.T. (2005). Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3′- Digallate (TF3). Evidence-Based Complementary and Alternative Medicine, 2(2), 209-215. https://doi.org/10.1093/ecam/neh081
  • Cheng, P.W., Ng, L.T., Chiang, L.C., & Lin, C.C. (2006). Antiviral Effects of Saikosaponins on Human Coronavirus 229E in Vitro. Clinical and Experimental Pharmacology and Physiology, 33(7), 612-616. https://doi.org/10.1111/j.1440-1681.2006.04415.x
  • Chiang, L.C., Chiang, W., Liu, M.C., & Lin, C.C. (2003). In Vitro Antiviral Activities of Caesalpinia Pulcherrima and Its Related Flavonoids. Journal of Antimicrobial Chemotherapy, 52(2), 194-198. https://doi.org/10.1093/jac/dkg291
  • Chiow, K.H., Phoon, M.C., Putti, T., Tan, B.K., & Chow, V.T. (2016). Evaluation of Antiviral Activities of Houttuynia Cordata Thunb. Extract, Quercetin, Quercetrin and Cinanserin on Murine Coronavirus and Dengue Virus Infection. Asian Pacific Journal of Tropical Medicine, 9(1), 1-7. https://doi.org/10.1016/j.apjtm.2015.12.002
  • Cinatl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H., & Doerr, H.W. (2003). Glycyrrhizin, an Active Component of Liquorice Roots, and Replication of SARS-Associated Coronavirus. Lancet, 361(9374), 2045-2046. https://doi.org/10.1016/S0140-6736(03)13615-X
  • Dai, W., Bi, J., Li, F., Wang, S., Huang, X., Meng, X., … Su, W. (2019). Antiviral Efficacy of Flavonoids against Enterovirus 71 Infection in Vitro and in Newborn Mice. Viruses, 11(7), pii: E625. https://doi.org/10.3390/v11070625
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Details

Primary Language Turkish
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Review Articles
Authors

Miray Ege 0000-0002-8872-5983

Mahfuz Elmastaş 0000-0002-7149-7427

Publication Date May 9, 2020
Published in Issue Year 2020 Volume: 1 Issue: 2

Cite

APA Ege, M., & Elmastaş, M. (2020). Antiviral Etkili Fitoterapötikler: Tıbbi Bitkiler ve Fitokimyasallar. Bütünleyici Ve Anadolu Tıbbı Dergisi, 1(2), 2-20.

Bütünleyici ve Anadolu Tıbbı Dergisi

Journal of Integrative and Anatolian Medicine